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THE 5AM PORTFOLIO: COMPANY PROFILES

achaogen

Achaogen

Achaogen (AKAO) is an infectious disease company developing small molecules to treat infection caused by multi-drug resistant bacterial infections. IPO in March 2014.

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Alexza

Alexza (ALXA) is a drug delivery company that develops drugs for delivery locally and systemically through the lungs. IPO in March 2006.

Ambrx

Ambrx

Ambrx is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics using an expanded genetic code.

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Arvinas

Arvinas is translating innovative protein degradation approaches into novel drugs for the treatment of cancer and other diseases.

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Atterocor

Atterocor is developing a small-molecule adrenal targeting therapeutic for adrenocortical carcinoma (ACC) and Cushing’s syndrome.

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Audentes

Audentes is development innovative treatments for people with serious, rare muscle diseases through adeno-associated virus (AAV) gene therapy.

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BIODESY

Biodesy has developed a unique and highly sensitive means of detecting conformational change in proteins and other biological molecules.

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Biotie

Biotie (BTH1V) is a biopharmaceutical company developing and commercializing products for neurodegenerative and psychiatric disorders. Acquired Synosia, a 5AM company, February 2011.

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Ceterix Orthopedics

Ceterix is a medical device company commercializing minimally invasive surgical tools within the arthroscopy market.

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Chrono

Chrono Therapeutics (CHRONO) is a pharmaceutical company founded in 2004 with a vision of transforming disease and addiction management to become the market leader in programmable passive transdermal drug delivery (TDD) that offers real-time behavioral support.

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Cidara

Cidara Therapeutics is applying its small molecule immunotherapy platform to treat life-threatening illnesses exacerbated by deficiencies of the human immune system.

Cleave

Cleave Biosciences

Cleave is developing small molecule therapeutics active in protein homeostasis pathways for treating cancer.

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DVS Sciences

DVS is commercializing mass cytometry instruments and reagents to characterize individual cells based on surface proteins, with various research and clinical applications. Acquired by Fluidigm (FLDM) in February 2014.

EntreMed

EntreMed

EntreMed (ENMD) is a clinical-stage pharmaceutical company developing targeted therapeutics for the treatment of cancer and inflammatory disease. Acquired Miikana, a 5AM company, in January 2006.

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Envoy

Envoy discovered novel drug targets and pharmaceuticals using platform technology for cell-specific gene expression profiling with a therapeutic focus on central nervous system and metabolic disease indications. Acquired by Takeda (TKPHF) in November 2012.

Epirus

Epirus

Epirus is developing a broad portfolio of biosimilar monoclonal antibodies and therapeutic proteins, focused in immunology and oncology.

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Flexion

Flexion (FLXN) is a clinical-stage pharmaceutical company developing therapeutics for the treatment of musculoskeletal diseases and pain. IPO in February 2014.

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Igenica

Igenica is a biopharmaceutical company discovering and developing antibody therapeutics for the treatment of cancer.

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Ikaria

Ikaria, formed from a combination of Ikaria and INO Therapeutics, is a commercial stage critical care therapeutics company in therapeutic gases. Acquired by Madison Dearborn Partners in February 2014.

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Ilypsa

Ilypsa was a biopharmaceutical company developing non-absorbed pharmaceuticals for renal and metabolic diseases. Acquired by Amgen (AMGN) July 2007.

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Incline

Incline was a hospital focused specialty pharmaceutical company developing a transdermal iontophoretic patch for patient controlled analgesia following surgery. Acquired by The Medicines Company (MDCO) in January 2013.

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Kalobios

KaloBios (KBIO) is a biopharmaceutical company developing human antibody therapeutics for oncology and respiratory diseases. IPO in January 2013.

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Kinestral

Kinestral is developing adaptive, dynamic glass for commercial, residential and automotive markets.

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Marcadia

Marcadia was a biopharmaceutical company developing therapeutics for the treatment of diabetes and obesity. Acquired by Roche (RHHBY) in December 2010.

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Novira

Novira is an antiviral drug discovery company that is focused on the development of first-in-class antiviral therapeutics for the treatment of serious diseases including chronic hepatitis B.

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Panomics

Panomics was a research instrument and reagents company which developed cell-based assays and instruments for quantitative multiplexed measurements of molecular events. Acquired by Affymetrix (AFFX) in December 2008.

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Pearl

Pearl was a biopharmaceutical company developing inhalable formulations for the treatment of respiratory diseases, including chronic obstructive pulmonary disease (COPD). Acquired by AstraZeneca (AZN) in June 2013.

PhaseRx

Phaserx

PhaseRx is an RNAi delivery company developing polymer-based approaches for systemic delivery of RNAi drugs.

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Pulmatrix

Pulmatrix is a clinical stage company with a unique inhaled dry powder platform advancing a pipeline of respiratory disease therapies.

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Relypsa

Relypsa (RLYP) is a clinical-stage biopharmaceutical company developing non-absorbed polymeric drugs, including a potassium-binding agent for hyperkalemia associated with cardiovascular and renal disease. IPO in November 2013.

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Rennovia

Rennovia is developing chemocatalytic processes for converting biorenewable feedstocks into high value and commodity chemicals.

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Ruiyi

RuiYi is discovering and developing biologic therapies in China, including monoclonal antibodies that target G protein coupled receptors (GPCRs).

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scPharmaceuticals

scPharmaceuticals is creating innovative and important new therapeutic options by administering drugs subcutaneously using a convenient two component delivery system suitable for patient self-administration.

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Semprus Biosciences

Semprus was a medical device company developing permanent antimicrobial & anti-biofouling surfaces for use on indwelling devices. Acquired by Teleflex (TFX) in May 2012.

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VBI Vaccines

VBI is an infectious disease company developing vaccines against Cytomegalovirus and other pathogens.

Viveve

Viveve

Viveve is commercializing a non-surgical, non-ablative medical device for use in women’s health.

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Wildcat

Wildcat is a high-throughput materials research company developing advanced battery materials for consumer and industrial applications.