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THE 5AM PORTFOLIO: COMPANY PROFILES

achaogen

Achaogen

Achaogen (AKAO) is a biopharmaceutical company developing small molecule therapeutics to treat infections caused by multi-drug resistant bacterial. IPO in March 2014.

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Alexza

Alexza (ALXA) is a biopharmaceutical company developing drugs for local and systemic delivery through the lung. IPO in March 2006.

Ambrx

Ambrx

Ambrx is a biopharmaceutical company which integrates recombinant protein synthesis with medicinal chemistry to develop protein drugs for a range of therapeutic areas. Acquired in June 2015.

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Aprea

Aprea is a biopharmaceutical company developing small molecule therapeutics for the treatment of cancer by reactivating mutant p53 tumor suppressor function.

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Arvinas

Arvinas is a biopharmaceutical company developing small molecule therapeutics that target protein degradation with applications in cancer and other diseases.

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Audentes

Audentes is a biotechnology company developing viral-based gene therapy for serious, rare diseases including genetic musculoskeletal disorders.

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Bellerophon

Bellerophon (BLPH) is a clinical-stage biopharmaceutical company developing novel drugs and devices for the treatment of cardiopulmonary and cardiac diseases. IPO in February 2015.

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BIODESY

Biodesy is a life science instrument and reagent company developing innovative technology systems for measuring protein conformational changes in real time.

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Bird Rock Bio

Bird Rock Bio is a clinical-stage biopharmaceutical company developing biologic therapies for the treatment of rheumatory arthritis and liver disease.

Calibrium

Calibrium

Calibrium is a biopharmaceutical company developing next generation insulins to treat diabetes and obesity. Acquired by Novo Nordisk (NVO) in August 2015.

Cellular-Research

Cellular Research

Cellular Research is a life science instrument company developing high resolution systems for the investigation of single cells and limited samples. Acquired by Becton Dickinson (BDX) in August 2015.

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Ceterix Orthopedics

Ceterix is a medical device company developing products to improve outcome for minimally invasive arthroscopic surgeries.

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Chrono

Chrono is a biopharmaceutical company developing wearable and programmable therapeutics leveraging novel drug delivery technologies.

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Cidara

Cidara (CDTX) is a clinical-stage biopharmaceutical company developing therapeutics for serious fungal infections. IPO in April 2015.

Cleave

Cleave Biosciences

Cleave is a clinical-stage biopharmaceutical company developing novel small molecule therapeutics that target protein homeostasis pathways for the treatment of cancer.

crinetics

Crinetics

Crinetics is a biopharmaceutical company developing oral small molecule therapeutics for endocrine diseases.

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DVS Sciences

DVS is a life science instrument company commercializing a mass cytometry for characterizing individual cells based on cell surface proteins. Acquired by Fluidigm (FLDM) in February 2014.

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Envoy

Envoy is a drug discovery company with a cell-specific gene expression profiling platform, enabling novel target discovery, such as for the central nervous system. Acquired by Takeda (TKPHF) in November 2012.

Epirus

Epirus

Epirus (EPRS) is a global biopharmaceutical company focused on pure-play biosimilar business to improve patient access to cost-effective medicines. Merged into public company in July 2014.

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Flexion

Flexion (FLXN) is a clinical-stage biopharmaceutical company developing intra-articular sustained release therapeutics for the treatment of musculoskeletal diseases. IPO in February 2014.

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Homology

Translating proprietary, next generation gene editing and gene therapy technology into novel treatments for patients with rare diseases.

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IDEAYA

Small molecules as novel personalized cancer therapies, leveraging synthetic lethality and immuno-oncology.

Igenica

Igenica

Igenica is a biopharmaceutical company developing antibodies and antibody-drug conjugates for the treatment of cancer.

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Ikaria

Ikaria is a commercial-stage biopharmaceutical company developing therapeutic gases for critical care applications. Acquired by Madison Dearborn Partners in February 2014.

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Ilypsa

Ilypsa is a biopharmaceutical company developing non-absorbed therapeutics for renal and metabolic diseases. Acquired by Amgen (AMGN) in July 2007.

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Incline

Incline is a biopharmaceutical company developing a transdermal iontophoretic patch for patient controlled analgesia following surgery. Acquired by The Medicines Company (MDCO) in January 2013.

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Kalobios

KaloBios (KBIO) is a biopharmaceutical company developing human antibody therapeutics for oncology and respiratory diseases. IPO in January 2013.

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Kinestral

Kinestral is a materials research company developing "adaptive" window technology for residential, automotive and commercial application.

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Marcadia

Marcadia is a biopharmaceutical company focused on developing therapeutics for the treatment of diabetes and obesity. Acquired by Roche (RHHBY) in December 2010.

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Miikana

Miikana is a clinical-stage biopharmaceutical company developing small molecule therapeutics for cancer. Acquired by EntreMed, a 5AM company, in January 2006.

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Millendo

Millendo is a biopharmaceutical company developing small molecule therapeutics for polycystic ovarian syndrome, adrenocortical carcinoma and congenital adrenal hyperplasia.

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Novira

Novira is a biopharmaceutical company developing small molecule therapeutics targeting viral capsid to treat Chronic Hepatitis B. Acquired by Johnson & Johnson (JNJ) in December 2015.

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Panomics

Panomics is a research instrument and reagents company which develops cell-based assays and instruments for quantitative multiplexed measurements of molecular events. Acquired by Affymetrix (AFFX) in December 2008.

Pear

Pear

Pear is a biopharmaceutical company combining existing medications with digital software to improve patient outcomes.

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Pearl

Pearl is a biopharmaceutical company developing inhalable formulations for the treatment of respiratory diseases such as chronic obstructive pulmonary disease. Acquired by AstraZeneca (AZN) in June 2013.

PhaseRx

PhaseRx

PhaseRx (PZRX) is a biotechnology company developing polymer-based technology to delivery mRNA nanoparticles for the treatment of orphan diseases. IPO in May 2016.

Portal

Portal Instruments

Portal is a biopharmaceutical company developing needle-free drug delivery system for the injection of large molecules.

PNI

Precision NanoSystems

PNI is a life science instrument and reagent company developing systems for the discovery and development of novel nanoparticles for biomedical use.

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Pulmatrix

Pulmatrix (PULM) is a pharmaceutical company developing innovative inhaled therapies to address serious pulmonary diseases. Merged into public company in June 2015.

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Purigen

Purigen is a life sciences instruments and reagents company developing novel systems for integrated sample extraction and preparation for genomics applications.

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Relypsa

Relypsa (RLYP) is a commercial-stage biopharmaceutical company developing non-absorbed polymeric drugs, including a potassium-binding agent for hyperkalemia associated with cardiovascular and renal diseases. IPO in November 2013.

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Rennovia

Rennovia is a materials research company developing chemocatalytic processes for converting biorenewable feedstocks into high value and commodity chemicals.

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scPharmaceuticals

scPharmaceuticals is a biopharmaceutical company developing therapeutics with enhanced drug delivery using a convenient, self-administering subcutaneous micropump technology.

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Semprus Biosciences

Semprus is a medical device company developing permanent antimicrobial and anti-biofouling surfaces for use on indwelling devices. Acquired by Teleflex (TFX) in May 2012.

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Spyryx

Spyryx is a biopharmaceutical company developing inhaled small peptide therapeutics for lung diseases, in particular cystic fibrosis and COPD.

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Startide

Startide is focused on the investment of innovative technologies in the research tools and diagnostics fields.

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Synosia

Synosia is a biopharmaceutical company developing and commercializing products for neurodegenerative and psychiatric disorders. Acquired by Biotie, a 5AM company, in February 2011.

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VBI Vaccines

VBI Vaccines is a biopharmaceutical company developing vaccines against Cytomegalovirus and other pathogens. Merged into public company in July 2014.

Viveve

Viveve

Viveve (VIVMF) is a medical device company commercializing a non-surgical, non-ablative medical device for use in women's health. Merged into public company in September 2014.

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Wildcat

Wildcat is a materials research company  developing advanced battery materials for consumer and industrial applications.